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Increlex IGF 1 LR3 10mg/ml 4ml Vial
Treatment of patients with T-cell acute lymphoblastic leukaemia and T-cell lymphoblastic lymphoma whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens.
Dosage: For adults the recommended dose is 1,500mg/m2 administered intravenously over two hours on days 1, 3 and 5 and repeated every 21 days. The recommended dose for children is 650mg/m2 administered intravenously over one hour daily for five consecutive days, repeated every 21 days. In clinical studies doses of 650mg/m2 and 1,500mg/m2 have both been used for patients aged 16 to 21 years, with similar efficacy and safety for both regimens.
Increlex IGF 1 LR3 10mg Per ml, 4ml vial
This kit equates to 40,000mcg of IGF
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Buy Increlex Online. Increlex (mecasermin) is a man-made form of insulin-like growth factor-1 (IGF-1), a substance that is normally produced in the body. IGF-1 is important for the growth of bones and muscles.
Increlex is use to treat growth failure in children whose bodies do not make enough IGF-1.
Increlex is not for use in children who have growth hormone deficiency, malnutrition, underactive thyroid, or those who are taking long-term steroid medications. Where to Buy Increlex Online.
Important information before you Buy Increlex Online
Increlex should not be given to a child who has cancer, or a child who has finished growing (the bone growth plates are closed).
Increlex is not for use in children who have growth hormone deficiency, malnutrition, underactive thyroid, or those who are taking long-term steroid medications.
Before your child receives this medicine, tell the doctor if your child has diabetes, kidney disease, liver disease, a curved spine (scoliosis), or if the child has ever had an allergic reaction to a preservative called benzyl alcohol.
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Increlex s injected under the skin. You and your child may be shown how to use injections at home. Make sure you fully understand how to give the injection and properly dispose of used needles and syringes.
Take care not to let your child’s blood sugar get too low while using this medicine. Know the signs of low blood sugar (hypoglycemia) and how to recognize them
Before taking this medicine
Your child should not use Increlex if he or she is allergic to mecasermin, or if:
- the child has cancer; or
- the child has finish growing and his or her bone growth plates are close.
To make sure Increlex is safe for your, tell the doctor if your child has:
- kidney disease;
- liver disease; or
- a curved spine (scoliosis).
It is not known whether Increlex will harm an unborn baby if used during pregnancy.
It is not known whether mecasermin passes into breast milk or if it could harm a nursing baby.
Increlex is not approved for use by anyone younger than 2 years old.
How is Increlex given?
Increlex is injected under the skin. You may be shown how to use injections at home. Do not give this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes. Do not inject this medicine into a vein.
Increlex is usually given twice per day, shortly before or after the child eats a meal or snack. Skip a dose if the child will miss a meal. Mecasermin can cause low blood sugar, which may be worse if the child does not eat.
Tell your doctor if your child has any changes in weight. Increlex doses are based on weight and any changes may affect the dose.
Your care provider will show you the best places on your child’s body to inject Increlex. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
Do not use the medicine if it looks cloudy or has particles in it. Call your pharmacist for new medicine.
While using Increlex, your child may need frequent examinations and medical tests. The child’s blood sugar may also need to be check often.
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Watch your child for signs of low blood sugar (hypoglycemia). Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar available in case the child has low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help the child in an emergency.
Keep track of how many days in a row your child has had low blood sugar symptoms after receiving a dose of this medicine.
Call the doctor if hypoglycemia symptoms do not get better after eating or drinking a sugar source.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Store this medicine in the refrigerator. Protect from light and do not freeze. Throw away the vial 30 days after opening it, even if it still contains unused Increlex.
Increlex dosing information
Usual Pediatric Dose for Primary IGF-1 Deficiency:
Initial dose: 0.4 to 0.8 mg/kg subcutaneously 2 times a day for at least 7 days
Maximum dose: 0.12 mg/kg subcutaneously 2 times a day
-Not a substitute to growth hormone (GH) for approved GH indications.
Uses: Treatment of growth failure in children with severe primary IGF-1 deficiency or with growth hormone (GH) gene deletion who have developed neutralizing antibodies to GH.