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Cannabidiol is a chemical in the Cannabis sativa plant, also known as marijuana or hemp. Over 80 chemicals, known as cannabinoids, have been identified in the Cannabis sativa plant. While delta-9-tetrahydrocannabinol (THC) is the major active ingredient in marijuana, cannabidiol is also obtained from hemp, which contains only very small amounts of THC.
The passage of the 2018 Farm Bill made it legal to sell hemp and hemp products in the U.S. But that doesn’t mean that all hemp-derived cannabidiol products are legal. Since cannabidiol has been studied as a new drug, it can’t be legally included in foods or dietary supplements. Also, cannabidiol can’t be included in products marketed with therapeutic claims. Cannabidiol can only be included in “cosmetic” products and only if it contains less than 0.3% THC. But there are still products labeled as dietary supplements on the market that contain cannabidiol. The amount of cannabidiol contained in these products is not always reported accurately on the product label.
Cannabidiol is most commonly used for seizure disorder (epilepsy). It is also used for anxiety, pain, a muscle disorder called dystonia, Parkinson disease, Crohn disease, and many other conditions, but there is no good scientific evidence to support these uses.
How does it work?
Cannabidiol has effects on the brain. The exact cause for these effects is not clear. However, cannabidiol seems to prevent the breakdown of a chemical in the brain that affects pain, mood, and mental function. Preventing the breakdown of this chemical and increasing its levels in the blood seems to reduce psychotic symptoms associated with conditions such as schizophrenia. Cannabidiol might also block some of the psychoactive effects of delta-9-tetrahydrocannabinol (THC). Also, cannabidiol seems to reduce pain and anxiety.
Buy Cannabidiol Online. Cannabidiol (CBD) is a phytocannabinoid discoverable in 1940. It is one of 113 identified cannabinoids in cannabis plants and accounts for up to 40% of the plant’s extract. As of 2019, clinical research on CBD included studies in relation to anxiety, cognition, movement disorders, and pain, but there is insufficient high-quality evidence that cannabidiol is effective for these conditions. Cannabidiol can be taken in multiple ways, including by inhalation of cannabis smoke or vapor, as an aerosol spray into the cheek, and by mouth.
It may be available in supply as CBD oil containing only CBD as the active ingredient (excluding tetrahydrocannabinol [THC] or terpenes), CBD-dominant hemp extract oil, capsules, dried cannabis, or prescription liquid solution.
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CBD does not have the same psychoactivity as THC, and may change the effects of THC on the body if both are present. As of 2018, the mechanism of action for its biological effects has not been determined. In the United States, the cannabidiol drug Epidiolex was approved by the Food and Drug Administration in 2018 for the treatment of two epilepsy disorders. Since cannabis is a Schedule I controlled substance in the United States, other CBD formulations remain illegal under federal law to prescribe for medical use or to use as an ingredient in dietary supplements or other foods. Where to Buy Cannabidiol Online.
Likely Effective for
- Seizure disorder (epilepsy). A specific cannabidiol product (Epidiolex, GW Pharmaceuticals) has been shown to reduce seizures in adults and children with various conditions that are linked with seizures. This product is a prescription drug for treating seizures cause by Dravet syndrome or Lennox-Gastaut syndrome. It is experimental to reduce seizures in people with tuberous sclerosis complex, Sturge-Weber syndrome, febrile infection-related epilepsy syndrome (FIRES), and specific genetic disorders that cause epileptic encephalopathy. But it’s not approve for treating these other types of seizures. This product is usually administer in combination with conventional anti-seizure medicines. Some cannabidiol products that are produce in a lab are also being in study for epilepsy. But research is limiting, and none of these products are approve as prescription drugs.
Possibly Effective for
- Multiple sclerosis (MS). A prescription-only nasal spray product (Sativex, GW Pharmaceuticals) containing both 9-delta-tetrahydrocannabinol (THC) and cannabidiol is seen to be effective for improving pain, muscle-tightness, and urination frequency in people with MS. This product is used in over 25 countries outside of the United States. But there is inconsistent evidence on the effectiveness of cannabidiol for symptoms of multiple sclerosis when it is used alone. Some early research suggests that using a cannabidiol spray under the tongue might improve pain and muscle tightness, but not muscle spasms, tiredness, bladder control, mobility, or well-being and quality of life in patients with MS.
Insufficient Evidence for
- Bipolar disorder. Early reports show that taking cannabidiol does not improve manic episodes in people with bipolar disorders.
- A type of inflammatory bowel disease (Crohn disease). Early research shows that taking cannabidiol does not reduce disease activity in adults with Crohn disease.
Early research shows that taking cannabidiol does not improve blood glucose levels, blood insulin levels, or HbA1c in adults with type 2 diabetes.
- A movement disorder marked by involuntary muscle contractions (dystonia). Early research suggests that taking cannabidiol daily for 6 weeks might improve dystonia by 20% to 50% in some people. Higher quality research is in need to confirm this. Best Place to Buy Cannabidiol Online.
- An inherited condition marked by learning disabilities (fragile- X syndrome). Early research found that applying cannabidiol gel might reduce anxiety and improve behavior in patients with fragile X syndrome.
- A condition in which a transplant attacks the body (graft-versus-host disease or GVHD). Graft-versus-host disease is a complication that can occur after a bone marrow transplant. In people with this condition, donor cells attack the person’s own cells. Early research shows that taking cannabidiol daily starting 7 days before bone marrow transplant and continuing for 30 days after transplant can extend the time it takes for a person to develop GVHD.
- An inherited brain disorder that affects movements, emotions, and thinking (Huntington disease). Early research shows that taking cannabidiol daily does not improve symptoms of Huntington’s disease.
Early research suggests that taking 160 mg of cannabidiol before bed improves sleep time in people with insomnia. However, lower doses do not have this effect. Cannabidiol also does not seem to help people fall asleep and might reduce the ability to recall dreams.
- Multiple sclerosis (MS). There is inconsistent evidence on the effectiveness of cannabidiol for symptoms of multiple sclerosis. Some early research suggests that using a cannabidiol spray under the tongue might improve pain and muscle tightness in people with MS. However, it does not appear to improve muscle spasms, tiredness, bladder control, the ability to move around, or well-being and quality of life.
- Withdrawal from heroin, morphine, and other opioid drugs. Early research shows that taking cannabidiol for 3 days reduces cravings and anxiety in people with heroin use disorder that are not using heroin or any other opioid drugs.
- Parkinson disease. Taking a single dose of cannabidiol can reduce anxiety during public speaking in people with Parkinson disease. Other early research shows that taking cannabidiol daily for 4 weeks improves psychotic symptoms in people with Parkinson disease and psychosis.
- Schizophrenia. Research on the use of cannabidiol for psychotic symptoms in people with schizophrenia is conflicting. Some early research suggests that taking cannabidiol four times daily. For 4 weeks improves psychotic symptoms and might be as effective as the antipsychotic medication amisulpride. However, other early research suggests that taking cannabidiol for 14 days is not beneficial. The conflicting results might be in relation to the cannabidiol dose use and duration of treatment.
- Quitting smoking. Early research suggests that inhaling cannabidiol with an inhaler for one week might reduce the number of cigarettes smoked by about 40% compared to baseline.
- A type of anxiety marked by fear in some or all social settings (social anxiety disorder). Some early research shows that taking cannabidiol 300 mg daily does not improve anxiety during public speaking in people with social anxiety disorder. But it might help with public speaking in people who don’t have social anxiety disorder. It might also help with general social anxiety. Also, some research suggests that taking a higher dose (400-600 mg) may improve anxiety associated with public speaking or medical imaging testing.
- A group of painful conditions that affect the jaw joint and muscle (temporomandibular disorders or TMD). Early research shows that applying an oil containing cannabidiol to the skin might improve nerve function in people with TMD.
- Nerve damage in the hands and feet (peripheral neuropathy).
- Other conditions.
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